Although Ganoderma (Lingzhi in Chinese) has been used as an elixir for thousands of years, its anti-aging effects still need to be clarified. Aging is related to immunoregulation, oxidation stress, and free radical product. Till now, Ganoderma exert life span elongation activities by inhibiting ROS production, lipid peroxidation, and advanced oxidation protein products; increasing production of mitochondrial electron transport complexes, SOD, CAT, GSH and GSH-Px, DPPH, and ABTS radical scavenger activities; and having immunomodulatory and antioxidant activity by increasing radical scavenging activity and ferric reducing antioxidant power. Ganoderma's anti-aging effect on human remains a mystery, and its potential mechanisms underlying anti-aging effect for its clinical application still need to be elucidated.
Keywords: Anti-aging; Free radical; Ganoderma; Immune; Lingzhi; Oxidation.