Brain is the most common site of lung cancer metastasis, and the incidenceis are higher if patients have driver gene mutation. Patients with brain metastasis have a poor prognosis; further, different treatment methods affect the disease status and prognosis. In recent years, with the development of precision medicine, gradual progress has been made in treatments for lung cancer patients with brain metastasis, especially for those with driver gene mutations. This review first highlights the challenges of brain metastasis treatments, and then summarizes the research progress regarding targeted therapies for patients with driver gene mutation-positive lung cancer and brain metastasis. This review could help guide clinical decision making for individualized treatment in daily clinical practice.
【中文题目：驱动基因阳性肺癌脑转移患者的 靶向治疗进展】 【中文摘要：脑是晚期肺癌转移最常见的部位，驱动基因阳性者脑转移发病率更高，肺癌脑转移患者预后较差，且不同治疗方式的选择影响肺癌脑转移患者的病程转归及预后。近年来，随着精准医学的发展，针对肺癌脑转移，尤其是具有特殊靶点的驱动基因阳性患者治疗方式的选择越来越成为人们的研究热点，并逐步取得进展。本文主要阐述了肺癌脑转移治疗存在的挑战，系统综述了驱动基因阳性肺癌脑转移的靶向治疗进展，以期在精准医学时代下，指导此类患者临床实践中个体化精准治疗方案的抉择。】 【中文关键词：肺肿瘤；脑转移；驱动基因；靶向治疗】.
Keywords: Brain metastasis; Driver gene mutations; Lung neoplasms; Targeted therapy.