Abstract
Borrelidins M-O (1-3), along with four previously known family members (4-7), were isolated from marine pulmonated mollusks Onchidium sp. associated Streptomyces olivaceus SCSIO LO13. The structures of 1-3 were elucidated by extensive spectral analyses of HR-ESI-MS, 1D and 2D NMR data. In addition, the cytotoxic and antibacterial activities of 1-7 were evaluated enabling us to propose some tentative structure-activity relationships (SARs), especially those involving modifications at C(22) and the moieties at C(7) and C(8) of the borrelidin scaffold.
Keywords:
Onchidium sp. derived actinomycete; antibacterial activity; borrelidin family; cytotoxicity; structure-activity relationships (SARs).
© 2019 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Fatty Alcohols / chemistry
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Fatty Alcohols / isolation & purification
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Fatty Alcohols / pharmacology
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Gastropoda / chemistry*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Streptomyces / chemistry*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Fatty Alcohols
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borrelidin