Interfacing the Cell with "Biomimetic Membrane Proteins"

Asaf Grupi; Idan Ashur; Nurit Degani-Katzav; Shimon Yudovich; Zehavit Shapira; Adan Marzouq; Lion Morgenstein; Yossi Mandel; Shimon Weiss

doi:10.1002/smll.201903006

Interfacing the Cell with "Biomimetic Membrane Proteins"

Small. 2019 Dec;15(52):e1903006. doi: 10.1002/smll.201903006. Epub 2019 Nov 25.

Authors

Asaf Grupi^{1

2}, Idan Ashur³, Nurit Degani-Katzav^{1

2}, Shimon Yudovich^{1

2}, Zehavit Shapira^{1

2}, Adan Marzouq^{1

2}, Lion Morgenstein^{1

2}, Yossi Mandel^{2

4}, Shimon Weiss^{1

2

5

6}

Affiliations

¹ Department of Physics, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
² Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
³ Agricultural Research Organization, The Volcani Center, Institute of Agricultural Engineering, Rishon LeZion, 7505101, Israel.
⁴ School of Optometry and Vision Science, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
⁵ Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, 90095, USA.
⁶ California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA.

PMID: 31765076
DOI: 10.1002/smll.201903006

Abstract

Integral membrane proteins mediate a myriad of cellular processes and are the target of many therapeutic drugs. Enhancement and extension of the functional scope of membrane proteins can be realized by membrane incorporation of engineered nanoparticles designed for specific diagnostic and therapeutic applications. In contrast to hydrophobic insertion of small amphiphilic molecules, delivery and membrane incorporation of particles on the nanometric scale poses a crucial barrier for technological development. In this perspective, the transformative potential of biomimetic membrane proteins (BMPs), current state of the art, and the barriers that need to be overcome in order to advance the field are discussed.

Keywords: biomimetic membrane proteins; membrane proteins; nanoparticles insertion into membranes; nanorods; quantum dots.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biomimetics / methods*
Membrane Proteins / chemistry*
Nanoparticles / chemistry
Nanotubes / chemistry
Quantum Dots

Substances

Membrane Proteins