The Relationships of High-Sensitivity C-Reactive Protein and Homocysteine Levels With Disease Activity, Damage Accrual, and Cardiovascular Risk in Systemic Lupus Erythematosus

Biol Res Nurs. 2020 Apr;22(2):169-177. doi: 10.1177/1099800419889192. Epub 2019 Nov 25.

Abstract

Results: hs-CRP correlated significantly with SLEDAI-2K (p = .036), SDI (p = .00), anti-dsDNA titers (p = .034), diabetes (p = .005), and obesity (p = .027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p = .032 and p < .001, respectively), TG/high-density lipoprotein cholesterol index (p = .020 and p = .001, respectively), and atherogenic index of plasma (p = .006 and p = .016, respectively). hs-CRP levels >3 mg/L correlated with SDI score (p = .012) and several CVD risk factors.

Discussion: Findings suggest SLE patients with elevated hs-CRP and/or Hcy have a higher prevalence of CVD risk factors.

Keywords: C-reactive protein; autoimmune; cardiovascular; homocysteine; inflammation; lupus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • C-Reactive Protein / adverse effects*
  • C-Reactive Protein / analysis*
  • Cardiovascular Diseases / chemically induced*
  • Female
  • Homocysteine / adverse effects*
  • Homocysteine / blood*
  • Humans
  • Lupus Erythematosus, Systemic / physiopathology*
  • Male
  • Middle Aged
  • Risk Factors
  • Symptom Assessment

Substances

  • Homocysteine
  • C-Reactive Protein