Precision Medicine in the Treatment of Melanoma

Abstract

Translational and clinical research advances have unveiled extensive cancer tumor cell heterogenicity. New understanding has prompted the practice-changing treatment of each cancer specific to its unique genetic construct. Among the earliest applications of this model was melanoma treatment. Survival rates increased significantly, with improvement each year. Genetic profiling allows further lesion classification, resulting in more personalized follow-up and treatment plans. Gene expression profiling allows the identification of specific mutations to direct targeted therapy and provides invaluable prognostic data. This article reviews the newest and most up-to-date advances in precision medicine within melanoma practice.

Keywords: DecisionDx-melanoma; Driver mutations; Gene-expression; Immunotherapy; Melanoma; Oncogene; Precision medicine.