Albumin nanocomposites with MnO2/Gd2O3 motifs for precise MR imaging of acute myocardial infarction in rabbit models

Fang Wang; Linyi Wen; Jing Liu; Wanlin Peng; Zihan Meng; Qixian Chen; Yao Wang; Bowen Ke; Yingkun Guo; Peng Mi

doi:10.1016/j.biomaterials.2019.119614

Albumin nanocomposites with MnO₂/Gd₂O₃ motifs for precise MR imaging of acute myocardial infarction in rabbit models

Biomaterials. 2020 Feb:230:119614. doi: 10.1016/j.biomaterials.2019.119614. Epub 2019 Nov 12.

Authors

Fang Wang¹, Linyi Wen², Jing Liu¹, Wanlin Peng², Zihan Meng¹, Qixian Chen³, Yao Wang¹, Bowen Ke⁴, Yingkun Guo⁵, Peng Mi⁶

Affiliations

¹ Department of Radiology, Center for Medical Imaging, And State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 10041, China.
² Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan, 610041, China.
³ School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Dalian, 116024, China.
⁴ Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
⁵ Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan, 610041, China. Electronic address: gykpanda@163.com.
⁶ Department of Radiology, Center for Medical Imaging, And State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 10041, China. Electronic address: mi@scu.edu.cn.

PMID: 31753475
DOI: 10.1016/j.biomaterials.2019.119614

Abstract

The severe mortality and morbidity of myocardial infarction requests appropriate and accurate detection. Considering pathological profile of the acidic myocardial infarction microenvironments, herein, the low pH-sensitive albumin nanocomposites with MnO₂ motifs (MnO₂@BSA) have been engineered for T₁-weighted MR imaging of myocardial infarction, while using non-pH-responsive Gd₂O₃@BSA nanocomposites as control. The nanocomposites were 20-30 nm in diameter with spheroid morphology. Besides, the MnO₂@BSA have exhibited pH-triggered releasing of Mn²⁺, demonstrating approximately 38-fold and 55-fold increased molecular relaxivity at acute myocardial infarction-mimicking pH 6.5 (13.08 mM^-1s^-1) and macrophage intracellular pH 5.0 (18.76 mM^-1s^-1) compared to the extremely low relaxivity (0.34 mM^-1s^-1) at normal physiological conditions (pH 7.4). However, the Gd₂O₃@BSA with molecular relaxivity approximately 10 mM^-1s^-1 were without pH-sensitive properties. Furthermore, the MnO₂@BSA have demonstrated high accumulation in the acute myocardial infarction regions and fast metabolism from the body after systemic injection, accounting high contrast enhancement for accurate MR imaging of acute myocardial infarction in rabbit models, demonstrating better diagnostic performance over the controls.

Keywords: Albumin nanoparticles; Early diagnosis; MRI; Myocardial infarction; pH responsive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Albumins
Animals
Contrast Media
Magnetic Resonance Imaging
Manganese Compounds*
Myocardial Infarction* / diagnostic imaging
Nanocomposites*
Nanoparticles*
Oxides
Rabbits

Substances

Albumins
Contrast Media
Manganese Compounds
Oxides