Outcomes and moderators of Early Start Denver Model intervention in young children with autism spectrum disorder delivered in a mixed individual and group setting

Autism. 2020 Apr;24(3):718-729. doi: 10.1177/1362361319888344. Epub 2019 Nov 21.

Abstract

Several studies have shown the efficacy and effectiveness of the Early Start Denver Model, both in university and in community-based settings. However, a limited number of studies have investigated predictors of outcomes. In this study, we examined outcomes in 32 children diagnosed with autism spectrum disorder after 1 year of community-based Early Start Denver Model intervention, with the aim to identify predictors of treatment objectives acquisition, as measured by the Early Start Denver Model Curriculum Checklist. At a group level, the participants demonstrated improvement in their communication as well as adaptive functioning skills, while they showed a decrease in symptom severity. The large heterogeneity in outcomes identified was related to the pre-treatment non-verbal abilities, symptom severity, action and gesture repertoire, and lexical comprehension. We discussed our results in terms of implications for developing "personalized" interventions for children with autism spectrum disorder.

Keywords: Early Start Denver Model; autism spectrum disorder; early intervention; predictors.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autism Spectrum Disorder / therapy*
  • Child, Preschool
  • Comprehension
  • Early Intervention, Educational*
  • Female
  • Gestures
  • Humans
  • Infant
  • Male
  • Treatment Outcome