Umbilical cord blood stearoyl-CoA desaturase index and lipoprotein lipase mass level in small-for-gestational age newborns

Prostaglandins Leukot Essent Fatty Acids. 2020 May:156:102028. doi: 10.1016/j.plefa.2019.102028. Epub 2019 Nov 6.

Abstract

We previously reported that triglyceride (TG) levels in small-for-gestational age (SGA) newborns were significantly higher than those in appropriate-for-gestational age (AGA) newborns. Stearoyl-CoA desaturase (SCD) activity is required for TG synthesis, while lipoprotein lipase mass (LPLm) facilitates TG clearance. The purpose of this study is to reveal whether SCD activity or LPLm is the cause of high TG levels in SGA newborns. Fifty-five newborns were classified as AGA (n = 42) and SGA (n = 13). Serum LPLm, TG and fatty acids in umbilical cord blood were analyzed. Then, [16:1 (n-7)]/ [16:0] and [18:1 (n-9)]/ [18:0] were calculated as SCD16 and SCD18 activities, respectively. The SGA group showed significantly higher TG levels and significantly lower LPLm levels than the AGA group. However, SCD16 and 18 activities were lower in SGA newborns than in AGA newborns. In conclusion, LPLm, rather than SCD activity may be involved in the increased TG levels in SGA newborns.

Keywords: Lipoprotein lipase mass; Small-for-gestational age; Stearoyl-CoA desaturase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Fetal Blood / enzymology*
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Small for Gestational Age / blood*
  • Lipoprotein Lipase / blood*
  • Male
  • Stearoyl-CoA Desaturase / blood*

Substances

  • Stearoyl-CoA Desaturase
  • Lipoprotein Lipase