Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus

Emerg Infect Dis. 2019 Dec;25(12):2335-2337. doi: 10.3201/eid2512.191111.

Abstract

We isolated and plaque purified IA76950-WT and IA70388-R, 2 porcine reproductive and respiratory syndrome viruses from pigs in the same herd in Iowa, USA, that exhibited coughing and had interstitial pneumonia. Phylogenetic and molecular evolutionary analysis indicated that IA70388-R is a natural recombinant from Fostera PRRSV vaccine and field strain IA76950-WT.

Keywords: PRRSV; United States; pigs; porcine reproductive and respiratory syndrome virus; recombination; swine; vaccine; viruses; wild type.

MeSH terms

  • Animals
  • Evolution, Molecular
  • Genome, Viral
  • Genomics / methods
  • Phylogeny
  • Porcine Reproductive and Respiratory Syndrome / prevention & control
  • Porcine Reproductive and Respiratory Syndrome / virology*
  • Porcine respiratory and reproductive syndrome virus / classification
  • Porcine respiratory and reproductive syndrome virus / physiology*
  • Recombination, Genetic*
  • Swine
  • Vaccines, Attenuated / genetics*
  • Vaccines, Attenuated / immunology
  • Viral Vaccines / genetics*
  • Viral Vaccines / immunology

Substances

  • Vaccines, Attenuated
  • Viral Vaccines