Prognostic role of Mini-Mental State Pediatric Examination (MMSPE) on neuropsychological functioning

Neurol Sci. 2020 Mar;41(3):619-623. doi: 10.1007/s10072-019-04141-6. Epub 2019 Nov 15.

Abstract

Objective: The aim of this study was to evaluate the ability of the Mini-Mental State Pediatric Examinations (MMSPE) in the individuation of neuropsychological impairments.

Method: MMSPE was administered to 60 children attending a primary or lower secondary school suffering from neurological diseases, admitted to our neuropsychology services. All children performed both a MMSPE examination and a neuropsychological evaluation. Results of neuropsychological evaluation and MMSPE were dichotomized. Positive predictive value (PPV), negative predictive value (NPV), and accuracy were also calculated.

Results: The diagnostic performance of MMSPE showed a good overall accuracy (0.83, CI 95% 0.64-0.91), NPV (0.81, CI 95% 0.73-1.00), PPV (0.87, CI 95% 0.68-0.94), specificity (0.91, CI 95% 0.81-1.00), sensitivity (0.74, CI 95% 0.57-0.90), and odds ratio of 28.5 (CI 95% 6.6-123), p < 0.001.

Conclusions: MMSPE has a good prognostic ability in predicting neuropsychological problems in the context of different neurological pediatric diseases. We suggest that this instrument could greatly improve pediatric clinical practice in identifying high-risk children.

Keywords: Children; Clinical practice; Cognitive; Predictive; Screening.

MeSH terms

  • Child
  • Cognitive Dysfunction / diagnosis*
  • Cognitive Dysfunction / etiology
  • Female
  • Humans
  • Male
  • Nervous System Diseases / complications
  • Nervous System Diseases / diagnosis*
  • Neuropsychological Tests / standards*
  • Predictive Value of Tests
  • Prognosis
  • Sensitivity and Specificity