The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium

Eur J Immunol. 2020 Feb;50(2):292-294. doi: 10.1002/eji.201948314. Epub 2019 Nov 25.

Abstract

Mice lacking CD4+ T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.

Keywords: B cells; CD4+ T cells; Citrobacter rodentium; NF-κB; c-Rel.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Bacterial / immunology
  • B-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / immunology
  • Citrobacter rodentium / immunology*
  • Enterobacteriaceae Infections / immunology*
  • Mice
  • NF-kappa B / immunology*
  • Proto-Oncogene Proteins c-rel / immunology*
  • Transcription, Genetic / immunology*

Substances

  • Antibodies, Bacterial
  • NF-kappa B
  • Proto-Oncogene Proteins c-rel