Iridium complex nanoparticle mediated radiopharmaceutical-excited phosphorescence imaging

Yutong Hou; Chenchen Wang; Ming Chen; Mingwei Wang; Guang Deng; Hong Yang; Zhiguo Zhou; Shiping Yang

doi:10.1039/c9cc07399j

Iridium complex nanoparticle mediated radiopharmaceutical-excited phosphorescence imaging

Chem Commun (Camb). 2019 Nov 28;55(96):14442-14445. doi: 10.1039/c9cc07399j.

Authors

Yutong Hou¹, Chenchen Wang, Ming Chen, Mingwei Wang, Guang Deng, Hong Yang, Zhiguo Zhou, Shiping Yang

Affiliation

¹ The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, 200234, China. yanghong@shnu.edu.cn shipingy@shnu.edu.cn.

PMID: 31724668
DOI: 10.1039/c9cc07399j

Abstract

We firstly perpared liposome coated [Ir(pq)2(bpy)]Cl (Ir@liposome) as a transducer for radiopharmaceutical (18F-FDG) excited phosphorescence imaging (REPI). Ir@liposome-based REPI exhibited deep tissue penetration and high signal-to-noise ratio in the tumor.

MeSH terms

Animals
Cell Line, Tumor
Coordination Complexes / chemistry*
Fluorodeoxyglucose F18 / chemistry
Humans
Iridium / chemistry*
Liposomes / chemistry
Mice
Nanoparticles / chemistry*
Optical Imaging / methods*
Radiopharmaceuticals / chemistry*
Signal-To-Noise Ratio

Substances

Coordination Complexes
Liposomes
Radiopharmaceuticals
Fluorodeoxyglucose F18
Iridium