Assessment of Memory Impairment in Early Diagnosis of Alzheimer's Disease

Martin Vyhnálek; Hana Marková; Jan Laczó; Rossana De Beni; Santo Di Nuovo

doi:10.2174/1567205016666191113125303

Assessment of Memory Impairment in Early Diagnosis of Alzheimer's Disease

Curr Alzheimer Res. 2019;16(11):975-985. doi: 10.2174/1567205016666191113125303.

Authors

Martin Vyhnálek^{1

2}, Hana Marková^{1

2}, Jan Laczó^{1

2}, Rossana De Beni³, Santo Di Nuovo⁴

Affiliations

¹ Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
² International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
³ Department of Psychology, University of Padua, Padua, Italy.
⁴ Department of Education, University of Catania, Catania, Italy.

PMID: 31724515
DOI: 10.2174/1567205016666191113125303

Abstract

Memory impairment has been considered as one of the earliest clinical hallmarks of Alzheimer's disease. This paper summarizes recent progress in the assessment of memory impairment in predementia stages. New promising approaches of memory assessment include evaluation of longitudinal cognitive changes, assessment of long-term memory loss, evaluation of subjective cognitive concerns and testing of other memory modalities, such as spatial memory. In addition, we describe new challenging memory tests based on memory binding paradigms that have been recently developed and are currently being validated.

Keywords: Alzheimer's disease; Elderly; memory binding; memory impairment; mild cognitive impairment; neuropsychological assessment; spatial memory; subjective cognitive decline..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Alzheimer Disease / complications*
Alzheimer Disease / diagnosis*
Early Diagnosis*
Female
Humans
Male
Memory Disorders / diagnosis*
Memory Disorders / etiology*