A case of pulmonary tumor thrombotic microangiopathy associated with lung cancer diagnosed by cell-block immunohistochemistry of pulmonary microvascular cytology

Hideaki Yamakawa; Tomohiro Oba; Hiroki Ohta; Yuta Tsukahara; Gen Kida; Emiri Tsumiyama; Tomotaka Nishizawa; Rie Kawabe; Shintaro Sato; Keiichi Akasaka; Masako Amano; Kazuyoshi Kuwano; Hidekazu Matsushima

doi:10.1016/j.rmcr.2019.100956

A case of pulmonary tumor thrombotic microangiopathy associated with lung cancer diagnosed by cell-block immunohistochemistry of pulmonary microvascular cytology

Respir Med Case Rep. 2019 Oct 23:28:100956. doi: 10.1016/j.rmcr.2019.100956. eCollection 2019.

Authors

Affiliations

¹ Department of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, Japan.
² Department of Respiratory Medicine, Tokyo Jikei University Hospital, Tokyo, Japan.

Abstract

Pulmonary tumor thrombotic microangiopathy (PTTM) is rare but should be considered as a possible diagnosis in patients with cancer. In this case, PTTM induced by lung cancer was more accurately diagnosed using cell block immunohistochemistry of pulmonary microvascular cytology (PMC) because we could confirm that lung adenocarcinoma was the origin of PTTM by the positive result of TTF-1 for atypical cells in PMC. The PMC procedure was minimally invasive and safer than lung biopsy. We believe that the cell block technique of PMC should be considered as one diagnostic option in PTTM.

Keywords: Cell block technique; Pulmonary microvascular cytology; Pulmonary tumor thrombotic microangiopathy.

Publication types

Case Reports