Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Affiliations

• ¹ Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49, box 1041, 3000 Leuven, Belgium.
• ² Research group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
• ³ Centre for Research in Molecular Medicine (CRiMM), University of Lahore, Pakistan.
• ⁴ Biocrystallography, KU Leuven, Herestraat 49, box 822, 3000 Leuven, Belgium.
• ⁵ University College London, Department of Structural and Molecular Biology, Gower Street, London, WC1E 6BT, UK.