Abstract
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
Keywords:
AmpC; amino acid numbering; beta-lactamases; class C beta-lactamase; conserved residue; nomenclature; structure-activity relationships.
Copyright © 2020 American Society for Microbiology.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / antagonists & inhibitors
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Bacterial Proteins / classification*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Gene Expression
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / enzymology
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Gram-Negative Bacteria / genetics*
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / enzymology
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Gram-Positive Bacteria / genetics*
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International Cooperation
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Mutation*
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Protein Structure, Secondary
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Sequence Alignment
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Sequence Homology, Amino Acid
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Terminology as Topic*
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beta-Lactam Resistance / genetics*
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beta-Lactamase Inhibitors / chemistry
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beta-Lactamase Inhibitors / pharmacology
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beta-Lactamases / classification*
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beta-Lactamases / genetics
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beta-Lactamases / metabolism
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beta-Lactams / chemistry
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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beta-Lactamase Inhibitors
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beta-Lactams
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AmpC beta-lactamases
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beta-Lactamases