Paroxismal non-kinesigenic dyskinesia and hemidystonia associated with silent celiac disease

Clin Neurol Neurosurg. 2020 Jan:188:105586. doi: 10.1016/j.clineuro.2019.105586. Epub 2019 Nov 4.

Abstract

Paroxismal non-kinesigenic dyskinesia (PNKD) is a rare movement disorder manifesting as choreatic/dystonic movements, usually lasting from minutes to up to 4 h, with perserved consciousness during attacks. Primary PNKD are idiopathic or genetic disorders while secondary PNKD are associated with various neurologic and medical conditions. We present a case with PNKD and right sided hemidystonia in association with celiac disease, responsive to gluten-free diet, not previously reported in available literature. In conclusion, diagnostic tests for celiac disease should be a part of etiological investigations in patients with otherwise unexplained movement disorders including PKND. Gluten free diet could produce a favorable clinical response in those patients.

Keywords: Celiac disease; Clinical presentation; PNKD (paroxysmal non-kinesigenic dyskinesia).

Publication types

  • Case Reports
  • Video-Audio Media

MeSH terms

  • Celiac Disease / complications*
  • Celiac Disease / diagnosis
  • Celiac Disease / diet therapy
  • Celiac Disease / physiopathology
  • Chorea / diet therapy
  • Chorea / etiology*
  • Chorea / physiopathology
  • Diet, Gluten-Free
  • Female
  • Humans
  • Undiagnosed Diseases
  • Young Adult

Supplementary concepts

  • Paroxysmal nonkinesigenic dyskinesia