Serum amyloid A: A potential biomarker of lung disorders

Lucia Vietri; Annalisa Fui; Laura Bergantini; Miriana d'Alessandro; Paolo Cameli; Piersante Sestini; Paola Rottoli; Elena Bargagli

doi:10.1016/j.resinv.2019.09.005

Serum amyloid A: A potential biomarker of lung disorders

Respir Investig. 2020 Jan;58(1):21-27. doi: 10.1016/j.resinv.2019.09.005. Epub 2019 Nov 8.

Authors

Lucia Vietri¹, Annalisa Fui², Laura Bergantini³, Miriana d'Alessandro⁴, Paolo Cameli⁵, Piersante Sestini⁶, Paola Rottoli⁷, Elena Bargagli⁸

Affiliations

¹ Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: lucia.vietri89@gmail.com.
² Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: annalisafui@gmail.com.
³ Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: Laurabergantini@gmail.com.
⁴ Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: miriana.dalessand@student.unisi.it.
⁵ Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: Paolocameli88@gmail.com.
⁶ Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: Sestini@unisi.it.
⁷ Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: rottoli@unisi.it.
⁸ Department of Medical and Surgical Sciences and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy. Electronic address: bargagli2@gmail.com.

PMID: 31708467
DOI: 10.1016/j.resinv.2019.09.005

Abstract

Serum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different lung diseases, including autoimmune disorders, chronic obstructive pulmonary diseases, obstructive sleep apnea syndrome, sarcoidosis, asthma, lung cancer, and other lung disorders, such as idiopathic pulmonary fibrosis, tuberculosis, radiation pneumonitis, and cystic fibrosis. This review focuses on the cellular and molecular interactions of serum amyloid A in different lung diseases and suggests this acute-phase protein as a prognostic marker.

Keywords: Acute-phase protein; Lung diseases; Prognosis; Serum amyloid A; Serum biomarkers.

Publication types

Review

MeSH terms

Amyloid / blood*
Biomarkers / blood
Humans
Lung Diseases / diagnosis*

Substances

Amyloid
Biomarkers