Manganese(II) coordination compounds of carboxylate non-steroidal anti-inflammatory drugs

Filitsa Dimiza; Marialena Lazou; Athanasios N Papadopoulos; Antonios G Hatzidimitriou; George Psomas

doi:10.1016/j.jinorgbio.2019.110906

Manganese(II) coordination compounds of carboxylate non-steroidal anti-inflammatory drugs

J Inorg Biochem. 2020 Feb:203:110906. doi: 10.1016/j.jinorgbio.2019.110906. Epub 2019 Oct 25.

Authors

Filitsa Dimiza¹, Marialena Lazou¹, Athanasios N Papadopoulos², Antonios G Hatzidimitriou¹, George Psomas³

Affiliations

¹ Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
² Department of Nutritional Sciences and Dietetics, International Hellenic University, Sindos, Thessaloniki, Greece.
³ Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. Electronic address: gepsomas@chem.auth.gr.

PMID: 31707332
DOI: 10.1016/j.jinorgbio.2019.110906

Abstract

Upon the interaction of MnCl₂ with the non-steroidal anti-inflammatory drugs oxaprozin or flufenamic acid in the presence of the nitrogen-donors 2,2'-bipyridine or 1,10-phenanthroline as co-ligands, one dinuclear and two trinuclear Mn(II) complexes were isolated. The complexes were characterized by diverse techniques. The complexes were evaluated for their scavenging activity against free radicals such as hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid). The in vitro binding affinity of the complexes to calf-thymus (CT) DNA and serum albumins was also monitored. In total, we may suggest that the complexes present promising scavenging activity against the radicals tested, and they may bind to CT DNA via intercalation and reversibly to serum albumins.

Keywords: DNA-binding; Interaction with albumins; Manganese(II) complexes; NSAIDs; Scavenging activity; Structures.

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Coordination Complexes / chemical synthesis*
DNA / chemistry
Flufenamic Acid / analogs & derivatives*
Manganese / chemistry*
Organometallic Compounds / chemical synthesis*
Oxaprozin / analogs & derivatives*
Protein Binding
Serum Albumin, Bovine / chemistry
Serum Albumin, Bovine / metabolism

Substances

Anti-Inflammatory Agents, Non-Steroidal
Coordination Complexes
Organometallic Compounds
Serum Albumin, Bovine
Manganese
Flufenamic Acid
DNA
calf thymus DNA
Oxaprozin