Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Elina Drakvik; Rolf Altenburger; Yasunobu Aoki; Thomas Backhaus; Tina Bahadori; Robert Barouki; Werner Brack; Mark T D Cronin; Barbara Demeneix; Susanne Hougaard Bennekou; Jacob van Klaveren; Carsten Kneuer; Marike Kolossa-Gehring; Erik Lebret; Leo Posthuma; Lena Reiber; Cynthia Rider; Joëlle Rüegg; Giuseppe Testa; Bart van der Burg; Hilko van der Voet; A Michael Warhurst; Bob van de Water; Kunihiko Yamazaki; Mattias Öberg; Åke Bergman

doi:10.1016/j.envint.2019.105267

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Environ Int. 2020 Jan:134:105267. doi: 10.1016/j.envint.2019.105267. Epub 2019 Nov 6.

Authors

Elina Drakvik¹, Rolf Altenburger², Yasunobu Aoki³, Thomas Backhaus⁴, Tina Bahadori⁵, Robert Barouki⁶, Werner Brack⁷, Mark T D Cronin⁸, Barbara Demeneix⁹, Susanne Hougaard Bennekou¹⁰, Jacob van Klaveren¹¹, Carsten Kneuer¹², Marike Kolossa-Gehring¹³, Erik Lebret¹⁴, Leo Posthuma¹⁵, Lena Reiber¹³, Cynthia Rider¹⁶, Joëlle Rüegg¹⁷, Giuseppe Testa¹⁸, Bart van der Burg¹⁹, Hilko van der Voet²⁰, A Michael Warhurst²¹, Bob van de Water²², Kunihiko Yamazaki²³, Mattias Öberg²⁴, Åke Bergman²⁵

Affiliations

¹ Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, SE-106 91 Stockholm, Sweden. Electronic address: elina.drakvik@ki.se.
² Helmholtz Centre for Environmental Research UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
³ National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
⁴ University of Gothenburg, Department of Biological and Environmental Sciences, Box 461, SE-405 30 Gothenburg, Sweden.
⁵ US Environmental Protection Agency, 1200 Pennsylvania Ave, NW, MC 8201R, Washington, DC 20460, USA.
⁶ Université de Paris, Inserm Unit 1124, 45 rue des Saints Pères, 75006 Paris, France.
⁷ Helmholtz Centre for Environmental Research UFZ, Permoserstr. 15, 04318 Leipzig, Germany; RWTH Aachen University Institute for Environmental Research, ABBt-aachen Biology, Worringerweg 1, 52074 Aachen, Germany.
⁸ Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool L3 3AF, UK.
⁹ Muséum National d'Histoire Naturelle (MNHN) UMR 7221 (CNRS/MNHN), 7 rue Cuvier, 75005 Paris, France.
¹⁰ Danish Technical University, FOOD, Kemitorvet 201, 2800 Kgs. Lyngby, Denmark.
¹¹ National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, the Netherlands.
¹² German Federal Institute for Risk Assessment, Pesticide Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
¹³ German Environment Agency (UBA), Corrensplatz 1, 14195 Berlin, Germany.
¹⁴ National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, the Netherlands; Institute of Risk Assessment Sciences - IRAS, Utrecht University, Yalelaan 2, 3584 CM Utrecht, the Netherlands.
¹⁵ National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, the Netherlands; Radboud University, Department of Environmental Science, Institute for Water and Wetland Research, Nijmegen, the Netherlands.
¹⁶ National Toxicology Program, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2-12, Research Triangle Park, NC 27709, USA.
¹⁷ Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Uppsala University, Department of Organismal Biology, Norbyvägen 18A, SE-752 36 Uppsala, Sweden.
¹⁸ University of Milan, Department of Oncology, Via S. Sofia, 9/1, 20122 Milan, Italy; IEO European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
¹⁹ BioDetection Systems, Science Park 406, 1098XH Amsterdam, the Netherlands.
²⁰ Wageningen University & Research, Droevendaalsesteeg 1, 6708PB Wageningen, the Netherlands.
²¹ CHEM Trust, 34b York Way, London N1 9AB, UK.
²² Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands.
²³ Ministry of the Environment, Japan, 1-2-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-8975, Japan.
²⁴ Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden.
²⁵ Stockholm University, ACES, SE-106 91 Stockholm, Sweden; Örebro University, Department of Science and Technology, SE-701 82 Örebro, Sweden; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Abstract

The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, "Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment" was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages.

Keywords: Chemical mixtures; Combined exposure; Environmental chemicals; Mixture risk assessment; Risk management.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Complex Mixtures
Hazardous Substances
Humans
Risk Assessment*

Substances

Complex Mixtures
Hazardous Substances

Abstract

Publication types

MeSH terms

Substances

Grants and funding