Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Jiefei Wang; Zhongjie Wang; Yong Zhong; Yan Zou; Chong Wang; Haigang Wu; Albert Lee; Weitao Yang; Xiao Wang; Yanjie Liu; Dongya Zhang; Jiliang Yan; Mingcong Hao; Meng Zheng; Roger Chung; Feng Bai; Bingyang Shi

doi:10.1016/j.biomaterials.2019.119576

Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Biomaterials. 2020 Jan:229:119576. doi: 10.1016/j.biomaterials.2019.119576. Epub 2019 Oct 24.

Authors

Jiefei Wang¹, Zhongjie Wang¹, Yong Zhong², Yan Zou³, Chong Wang⁴, Haigang Wu¹, Albert Lee⁵, Weitao Yang⁶, Xiao Wang², Yanjie Liu¹, Dongya Zhang¹, Jiliang Yan¹, Mingcong Hao¹, Meng Zheng¹, Roger Chung⁵, Feng Bai⁷, Bingyang Shi⁸

Affiliations

¹ International Joint Center for Biomedical Innovation, School of Life Sciences Henan University, Kaifeng, 475004, China.
² Key Laboratory for Special Functional Materials of Ministry of Education, National & Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology, School of Materials Science and Engineering, Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng, 475004, China.
³ International Joint Center for Biomedical Innovation, School of Life Sciences Henan University, Kaifeng, 475004, China; Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
⁴ Luohe Central Hospital, Luohe, 462000, China.
⁵ Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
⁶ Institute of Photomedicine, Shanghai Skin Disease Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, 200443, China.
⁷ Key Laboratory for Special Functional Materials of Ministry of Education, National & Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology, School of Materials Science and Engineering, Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng, 475004, China. Electronic address: baifengsun@126.com.
⁸ International Joint Center for Biomedical Innovation, School of Life Sciences Henan University, Kaifeng, 475004, China; Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia. Electronic address: bs@henu.edu.cn.

PMID: 31704467
DOI: 10.1016/j.biomaterials.2019.119576

Abstract

Dual-modal imaging guided photodynamic therapy (PDT) of multifunctional nanocomposites holds great promise for precision tumor theranostics. However, poor heterogeneous interfacial compatibility between functional components, low hydrophilicity and complicated preparation of nanocomposites remain major obstacles for further bioapplication. Herein, a facile central metal-derived co-assembly strategy is developed to effectively integrate gadolinium porphyrin (GdTPP) contrast agent and Zinc porphyrin (ZnTPP) photosensitizer into a homogeneous GdTPP/ZnTPP nanocomposites (GZNs). GZNs possesses the following advantages: (1) Greatly improved interfacial compatibility facilitated by incorporating two metalporphyrins with same group (phenyl-) and different central metal atoms (Zn and Gd) leading to higher yield (4.7-5 fold) than either monocomponent nanoparticles. (2) Poor dispersity of GdTPP nanoparticles is greatly improved after integrating with ZnTPP blocks. (3) The GZNs inherit excellent fluorescence imaging, high relaxation rate (8.18 mM^-1 s^-1) and singlet oxygen production from two raw metalporphyrins. After camouflaging with homotypic cancer cell membrane for immunologic escape, the HeLa membrane coated GZNs (mGZNs) show enhanced in vivo MR/FL imaging guided anti-tumor targeting efficiency of 80.6% for HeLa cells. Our new strategy using central metal-derived co-assembly of homogeneous building blocks greatly improves interfacial compatibility to achieve combined functions for visualized cancer theranostics.

Keywords: Co-assembly; Dual-modal imaging; Nanocomposites; PDT; Porphyrin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetics
Gadolinium
HeLa Cells
Humans
Metalloporphyrins
Nanocomposites*
Nanoparticles*
Photochemotherapy*
Porphyrins*

Substances

Metalloporphyrins
Porphyrins
zinc-tetrakis(p-sulfonatophenyl)porphyrin
zinc hematoporphyrin
Gadolinium