Successful treatment of septic shock due to NDM-1-producing Klebsiella pneumoniae using ceftazidime/avibactam combined with aztreonam in solid organ transplant recipients: report of two cases

Int J Antimicrob Agents. 2020 Jan;55(1):105842. doi: 10.1016/j.ijantimicag.2019.10.023. Epub 2019 Nov 5.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Azabicyclo Compounds / therapeutic use*
  • Aztreonam / therapeutic use*
  • Ceftazidime / therapeutic use*
  • Drug Combinations
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Gene Expression Regulation, Bacterial
  • Humans
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / metabolism
  • Middle Aged
  • Organ Transplantation / adverse effects
  • Shock, Septic / drug therapy
  • Shock, Septic / microbiology*
  • Transplant Recipients*
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Drug Combinations
  • avibactam, ceftazidime drug combination
  • Ceftazidime
  • beta-Lactamases
  • beta-lactamase NDM-1
  • Aztreonam