Nonpathogenic Bacteria as Targets in Antimicrobial High-Throughput Screening

Paula Yagüe; Nathaly Gonzalez-Quiñonez; Angel Manteca

doi:10.1016/j.tim.2019.10.005

Nonpathogenic Bacteria as Targets in Antimicrobial High-Throughput Screening

Trends Microbiol. 2020 Jan;28(1):1-2. doi: 10.1016/j.tim.2019.10.005. Epub 2019 Nov 6.

Authors

Paula Yagüe¹, Nathaly Gonzalez-Quiñonez¹, Angel Manteca²

Affiliations

¹ Área de Microbiología, Departamento de Biología Funcional, IUOPA, ISPA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain.
² Área de Microbiología, Departamento de Biología Funcional, IUOPA, ISPA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain. Electronic address: mantecaangel@uniovi.es.

Abstract

Antimicrobial screening usually analyses the effects of natural or synthetic molecules against pathogens. McAuley et al. changed this paradigm, testing the effect of synthetic compounds against the sporulation of the nonpathogenic bacterium Streptomyces venezuelae. They discovered a novel DNA-targeting antibiotic effective against pathogens.

Keywords: Streptomyces; antimicrobials; high-throughput screening; sporulation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Infective Agents*
DNA Gyrase
Streptomyces*

Substances

Anti-Bacterial Agents
Anti-Infective Agents
DNA Gyrase

Supplementary concepts

Streptomyces venezuelae