Data on cytotoxic activity of an Artemisia annua herbal preparation and validation of the quantification method for active ingredient analysis

Michael Schmiech; Sophia J Lang; Tatiana Syrovets; Thomas Simmet

doi:10.1016/j.dib.2019.104635

Data on cytotoxic activity of an Artemisia annua herbal preparation and validation of the quantification method for active ingredient analysis

Data Brief. 2019 Oct 15:27:104635. doi: 10.1016/j.dib.2019.104635. eCollection 2019 Dec.

Authors

Michael Schmiech¹, Sophia J Lang¹, Tatiana Syrovets¹, Thomas Simmet¹

Affiliation

¹ Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.

Abstract

The data in this article contain supporting information for the research manuscript entitled "Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients" by Lang et al. [1]. Momundo Artemisia annua extract and an acetonitrile fraction thereof induce apoptosis in MDA-MB-231 triple negative breast cancer cells as shown by XTT viability assay and induction of the subG₀/G₁ cell population by flow cytometric analysis. Furthermore, the HPLC-DAD method used to characterize the Artemisia annua herbal preparation as well as UHPLC-MS/MS method used to quantify the most abundant compounds in the extract and its validation are presented.

Keywords: Apoptosis; Artemisia annua; Breast cancer; Caspase 8; Cytotoxicity; HPLC-MS/MS; Nutraceutical; Triple-negative breast cancer.