Prioritization of pharmaceuticals in water environment in China based on environmental criteria and risk analysis of top-priority pharmaceuticals

Abstract

Numerous studies have shown that a wide range of pharmaceuticals are present in the environment and many of their adverse biological effects on the aquatic ecosystem and human health are unknown. Due to the high population density and large number of pharmaceuticals produced and consumed in China, a systematic approach is needed to identify pharmaceuticals that require greater attention. The present study provides a ranking of pharmaceuticals in China in terms of their occurrence (O), persistence, bioaccumulation, and toxicity (PBT) based on the predicted environmental concentration (PEC). The total and partial ranking method implemented in the decision analysis by ranking techniques (DART) tool was used, which is an easy-to-use tool for the analysis of datasets. Using the DART approach, 10 pharmaceuticals were selected as priority compounds. These pharmaceuticals included antibiotics, anti-inflammatory and antilipidemic. In order to identify the characteristics of the priority pharmaceuticals, ecotoxicological endpoints were considered. The results of this study and the priority list facilitate the selection of candidate pollutants in future monitoring studies.

Keywords: Bioaccumulation; Occurrence; Persistence; Pharmaceutical; Priority; Toxicity.