STAT-ART: The Promise and Practice of a Rapid Palliative Single Session of MR-Guided Online Adaptive Radiotherapy (ART)

Kathryn E Mittauer; Patrick M Hill; Mark W Geurts; Anna-Maria De Costa; Randall J Kimple; Michael F Bassetti; John E Bayouth

doi:10.3389/fonc.2019.01013

STAT-ART: The Promise and Practice of a Rapid Palliative Single Session of MR-Guided Online Adaptive Radiotherapy (ART)

Front Oncol. 2019 Oct 22:9:1013. doi: 10.3389/fonc.2019.01013. eCollection 2019.

Authors

Kathryn E Mittauer^{1

2}, Patrick M Hill¹, Mark W Geurts^{1

3}, Anna-Maria De Costa¹, Randall J Kimple¹, Michael F Bassetti¹, John E Bayouth¹

Affiliations

¹ Department of Human Oncology, UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States.
² Department of Radiation Oncology, Baptist Health South Florida, Miami Cancer Institute, Miami, FL, United States.
³ Department of Radiation Oncology, Aspirus Wausau Hospital, Aspirus Inc., Wausau, WI, United States.

Abstract

This work describes a novel application of MR-guided online adaptive radiotherapy (MRgoART) in the management of patients whom urgent palliative care is indicated using statum-adaptive radiotherapy (STAT-ART). The implementation of STAT-ART, as performed at our institution, is presented including a discussion of the advantages and limitations compared to the standard of care for palliative radiotherapy on conventional c-arm linacs. MR-based treatment planning techniques of STAT-ART for density overrides and deformable image registration (DIR) of diagnostic CT to the treatment MR are also addressed.

Keywords: ART; MR-guidance; MR-guided radiotherapy; MRgRT; MRgoART; deformable image registration; online adaptive radiotherapy; palliative radiation.