Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia

Woo Yeup Jeong; Sodam Kim; So Yun Lee; Hyeseon Lee; Dong Wook Han; Seung Yun Yang; Ki Su Kim

doi:10.1186/s40824-019-0164-z

Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia

Biomater Res. 2019 Oct 31:23:16. doi: 10.1186/s40824-019-0164-z. eCollection 2019.

Authors

Woo Yeup Jeong^#¹, Sodam Kim^#², So Yun Lee¹, Hyeseon Lee², Dong Wook Han³, Seung Yun Yang², Ki Su Kim¹

Affiliations

¹ 1Department of Organic Materials Science and Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan, 46241 Republic of Korea.
² 2Department of Biomaterials Science, Life and Industry Convergence Institute, Pusan National University, 1268-50 Samrangjin-ro, Miryang, 50463 Republic of Korea.
³ 3Department of Optic-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan, 46241 Republic of Korea.

^# Contributed equally.

Abstract

Background: Alopecia has become a very common disease that many people around the world are suffered. Minoxidil (MXD) is the most well-known commercialized drug in its treatment. However, in the case of MXD administration, there are some problems with low efficiency of transdermal delivery and additional side effects.

Method: MXD and Rhodamine B (Rho B) are encapsulated in poly(Lactide-co-Glycolide) grafted hyaluronate nanoparticles (HA-PLGA/MXD NPs, HA-PLGA/Rho B NPs) which is prepared with W/O/W solvent evaporation method. After then, the investigation is carried out to confirm the feasibility of NPs in alopecia treatment.

Results: Both of HA-PLGA/MXD NPs and HA-PLGA/Rho B NPs are successfully prepared. In addition, it is confirmed that HA-PLGA NPs sufficiently delivered to cells without any significant cytotoxicity by cell viability, cellular uptake and skin permeation test.

Conclusion: Taken together, HA-PLGA NPs as a transdermal delivery carrier to hair follicle cells can be exploited to develop the efficient and effective platform of transdermal drug delivery for the treatment of various diseases.

Keywords: Alopecia; Hyaluronate; Minoxidil; Poly(Lactide-co-Glycolide); Transdermal drug delivery.