Plastic binding feature of polymyxins: the effect on MIC susceptibility measurements

Toktam Sharafi; Abdollah Ardebili

doi:10.2147/IDR.S219130

Plastic binding feature of polymyxins: the effect on MIC susceptibility measurements

Infect Drug Resist. 2019 Aug 27:12:2649-2653. doi: 10.2147/IDR.S219130. eCollection 2019.

Authors

Toktam Sharafi^{1

2}, Abdollah Ardebili^{1

2}

Affiliations

¹ Infectious Disease Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
² Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Abstract

The loss of polycationic antimicrobial peptides, polymyxins, due to adhesion to plastics is an important subject matter that influences in vitro susceptibility testing, including minimum inhibitory concentration (MIC) assays. This review reminds us that this issue can serve as a significant source of variation in the MIC values for polymyxins against Gram-negative bacteria.

Keywords: Gram-negative bacteria; MIC; broth microdilution; colistin; polymyxin B.