Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Patrick D Bosshart; David Kalbermatter; Sara Bonetti; Dimitrios Fotiadis

doi:10.1080/23723556.2019.1646605

Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Mol Cell Oncol. 2019 Aug 27;6(6):e1646605. doi: 10.1080/23723556.2019.1646605. eCollection 2019.

Authors

Patrick D Bosshart¹, David Kalbermatter¹, Sara Bonetti¹, Dimitrios Fotiadis¹

Affiliation

¹ Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.

Abstract

Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure-function analysis provides insights into the molecular working mechanisms of ligand binding and L-lactate transport.

Keywords: L-lactate transporter; SLC16 family; monocarboxylate transporter; structure; transport mechanism.

Grants and funding

The project was financially supported by the University of Bern, the Swiss National Science Foundation (grant 310030_184980 to Dimitrios Fotiadis), and the NCCR TransCure.