Peroxidase-like Activity of Metal-Organic Framework [Cu(PDA)(DMF)] and Its Application for Colorimetric Detection of Dopamine

ACS Appl Mater Interfaces. 2019 Nov 27;11(47):44466-44473. doi: 10.1021/acsami.9b17488. Epub 2019 Nov 18.

Abstract

A metal-organic framework (MOF) [Cu(PDA)(DMF)] was synthesized under mild mixed solvothermal conditions. It is constructed by 1,10-phenanthroline-2,9-dicarboxylic acid (H2PDA) and Cu2+ ions. The complex exhibits high peroxidase-like activity and can catalytically oxidize the colorless substrate 3,3',5,5'-tetramethylbenzidine to a blue product in the presence of H2O2. However, the peroxidase-like activity of [Cu(PDA)(DMF)] can be potently inhibited in the presence of dopamine. Based on this phenomenon, the colorimetric detection of dopamine was demonstrated with good selectivity and high sensitivity. [Cu(PDA)(DMF)] showed good stability and robust catalytic activity, which has been employed in the detection of dopamine in human urine and pharmaceutical samples.

Keywords: copper; dopamine; metal−organic frameworks; nanozyme; peroxidase.

Publication types

  • Evaluation Study

MeSH terms

  • Benzidines / chemistry
  • Colorimetry / instrumentation
  • Colorimetry / methods*
  • Dopamine / urine*
  • Humans
  • Hydrogen Peroxide / chemistry
  • Metal-Organic Frameworks / chemistry*
  • Oxidation-Reduction
  • Peroxidases / chemistry
  • Pharmaceutical Preparations / analysis

Substances

  • Benzidines
  • Metal-Organic Frameworks
  • Pharmaceutical Preparations
  • 3,3',5,5'-tetramethylbenzidine
  • Hydrogen Peroxide
  • Peroxidases
  • Dopamine