Association between Serum Ferritin and Cognitive Function in Early Childhood

J Pediatr. 2020 Feb:217:189-191.e2. doi: 10.1016/j.jpeds.2019.09.051. Epub 2019 Nov 2.

Abstract

In infants 1-3 years of age, we found higher serum ferritin values associated with higher cognitive function, as measured by the Mullen Scales of Early Learning (P = .02 for the nonlinear relationship). A serum ferritin of 17 μg/L corresponded to the maximum level of cognition, beyond which there was no meaningful improvement. TRIAL REGISTRATION: Clinicaltrials.gov NCT01481766 and NCT01869530.

Keywords: hemoglobin; iron deficiency.

MeSH terms

  • Anemia, Iron-Deficiency / blood*
  • Anemia, Iron-Deficiency / physiopathology
  • Biomarkers / blood
  • Child Development / physiology*
  • Child, Preschool
  • Cognition / physiology*
  • Female
  • Ferritins / blood*
  • Hemoglobins / metabolism
  • Humans
  • Infant
  • Male

Substances

  • Biomarkers
  • Hemoglobins
  • Ferritins

Associated data

  • ClinicalTrials.gov/NCT01481766
  • ClinicalTrials.gov/NCT01869530