Benefits of statins in chronic obstructive pulmonary disease patients with pulmonary hypertension: A meta-analysis

Eur J Intern Med. 2019 Dec:70:39-42. doi: 10.1016/j.ejim.2019.09.009. Epub 2019 Oct 31.

Abstract

Purpose: This meta-analysis was performed to evaluate the efficacy of statins in chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH).

Methods: A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of COPD-PH with the statins, compared with placebo, were reviewed. Studies were pooled to weighted mean differences (WMD), with 95% confidence interval (CI).

Results: Five trials (enrolling 270 participants) met the inclusion criteria. Compared with placebo, the statins presented significant effects on systolic pulmonary artery pressure (WMD -4.52 mmHg; 95% CI -6.32 to -2.72 mmHg) and 6-min walk distance (6MWD) (WMD 32.46 m; 95% CI 13.63-51.29 m).

Conclusions: Statins therapy significantly improves PH and 6MWD in COPD patients with PH.

Keywords: COPD; Meta-analysis; Pulmonary hypertension; Stasins.

Publication types

  • Meta-Analysis

MeSH terms

  • Blood Pressure / drug effects
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hypertension, Pulmonary / complications
  • Hypertension, Pulmonary / drug therapy*
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / drug therapy*
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Walk Test

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors