Polypharmacy at discharge in older hospitalised patients in Vietnam and its association with frailty

Australas J Ageing. 2020 Sep;39(3):230-236. doi: 10.1111/ajag.12722. Epub 2019 Nov 1.

Abstract

Objectives: To investigate the prevalence of polypharmacy and the common drugs prescribed at discharge in frail and non-frail older inpatients, and to examine whether frailty is significantly associated with polypharmacy.

Methods: Cross-sectional analysis from data of a study about the prevalence of frailty in older inpatients in Vietnam in 2015. Polypharmacy was defined as using ≥5 medications. Frailty was defined by Fried's frailty criteria.

Results: There were 382 participants, mean age 76.4, 56.5% female and 35.9% frail. At discharge, 59.2% had polypharmacy (62.8% in the frail and 57.1% in the non-frail). Vitamin/supplements were the most common drugs prescribed, followed by antiplatelets. Frailty was not significantly associated with polypharmacy (adjusted OR 1.45, 95% CI 0.89-2.34).

Conclusions: The prevalence of polypharmacy at discharge was high in both frail and non-frail participants. The association between frailty and polypharmacy needs to be investigated further in multicentre studies with larger sample sizes in Vietnam.

Keywords: frailty; medication; older people; polypharmacy.

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Female
  • Frail Elderly
  • Frailty* / diagnosis
  • Frailty* / epidemiology
  • Geriatric Assessment
  • Humans
  • Male
  • Patient Discharge
  • Polypharmacy
  • Vietnam / epidemiology