Bioactive triterpenoid saponins from the tubers of Hemsleya amabilis Diels

Yuexian Jin; Xiaolei Zhou; Junshan Yang; Xudong Xu; Jing Zhang; Guoxu Ma

doi:10.1016/j.fitote.2019.104404

Bioactive triterpenoid saponins from the tubers of Hemsleya amabilis Diels

Fitoterapia. 2019 Nov:139:104404. doi: 10.1016/j.fitote.2019.104404. Epub 2019 Oct 30.

Authors

Yuexian Jin¹, Xiaolei Zhou², Junshan Yang³, Xudong Xu³, Jing Zhang⁴, Guoxu Ma⁵

Affiliations

¹ Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences，Beijing 100193, China; College of Chinese Medicine Materials, Jilin Agricultural University, Changchun 130118, China.
² Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi Province 530023, China.
³ Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences，Beijing 100193, China.
⁴ College of Chinese Medicine Materials, Jilin Agricultural University, Changchun 130118, China.
⁵ Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences，Beijing 100193, China. Electronic address: mgxfl8785@163.com.

PMID: 31676394
DOI: 10.1016/j.fitote.2019.104404

Abstract

Five new cucurbitane-type triterpenoid saponins Xuedanosides A-E (1-5) were isolated from the medicinal plant Hemsleya amabilis Diels by silica gel column, octadecylsilyl (ODS) column, and pre-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Separated compounds were evaluated for their cytotoxic activity in HeLa, HCT-8, MCF-7 and HepG2 human cancer cell lines, and compounds 1 and 2 showed significant effects against HeLa cells with IC₅₀ values of 3.21 and 8.57 μM, respectively.

Keywords: Cucurbitane-type triterpenoid saponins; Cytotoxic activity; Hemsleya amabilis Diels.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
China
Cucurbitaceae / chemistry*
Glycosides
Humans
Molecular Structure
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Tubers / chemistry*
Saponins / isolation & purification
Saponins / pharmacology*
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Glycosides
Phytochemicals
Saponins
Triterpenes
cucurbitane