Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability

Nanomedicine. 2020 Feb:24:102117. doi: 10.1016/j.nano.2019.102117. Epub 2019 Oct 30.

Abstract

Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. Additionally, the utilization of derivatives of Vit C and the development of micro and nanoencapsulated delivery systems have been highlighted. In this article, the multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability.

Keywords: Ascorbic acid; Drug delivery; Liposomes; Microemulsions; Nanoparticles; Targeting.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antioxidants* / chemistry
  • Antioxidants* / therapeutic use
  • Ascorbic Acid* / chemistry
  • Ascorbic Acid* / therapeutic use
  • Chemistry, Pharmaceutical
  • Drug Delivery Systems*
  • Drug Stability
  • Nanostructures* / chemistry
  • Nanostructures* / therapeutic use
  • Vitamins* / chemistry
  • Vitamins* / therapeutic use

Substances

  • Antioxidants
  • Vitamins
  • Ascorbic Acid