Modeling Parkinson's Disease Heterogeneity to Accelerate Precision Medicine

Gonzalo H Olivares; Patricio Olguín; Andrés D Klein

doi:10.1016/j.molmed.2019.09.004

Modeling Parkinson's Disease Heterogeneity to Accelerate Precision Medicine

Trends Mol Med. 2019 Dec;25(12):1052-1055. doi: 10.1016/j.molmed.2019.09.004. Epub 2019 Oct 30.

Authors

Gonzalo H Olivares¹, Patricio Olguín², Andrés D Klein³

Affiliations

¹ Program in Human Genetics, Institute of Biomedical Sciences, Biomedical Neuroscience Institute, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
² Program in Human Genetics, Institute of Biomedical Sciences, Biomedical Neuroscience Institute, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address: patricioolguin@med.uchile.cl.
³ Centro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Avenida Las Condes 12461, Santiago 7590943, Chile. Electronic address: andresklein@udd.cl.

PMID: 31676188
DOI: 10.1016/j.molmed.2019.09.004

Abstract

A mechanistic understanding of the diverse clinical manifestations of Parkinson's disease (PD) and variable patient response to treatments is lacking. Genetically diverse PD model organisms can be used to map modifier genes and understand clinically relevant phenotypes of varying severity. This strategy can accelerate the pace of discoveries for precision medicine purposes.

Keywords: Parkinson’s disease; customized therapies; genome-wide association studies; inbred animal organisms; modifier genes; precision medicine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Parkinson Disease / genetics*
Phenotype
Precision Medicine*