Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol

Ther Deliv. 2019 Oct;10(10):626-641. doi: 10.4155/tde-2019-0054. Epub 2019 Nov 1.

Abstract

Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.

Keywords: dissolution; microscopy; resveratrol; self-emulsifying drug delivery systems; solubility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Carboxymethylcellulose Sodium / chemistry
  • Chemistry, Pharmaceutical
  • Drug Compounding / methods*
  • Drug Delivery Systems / methods*
  • Drug Development*
  • Emulsions
  • Excipients / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Resveratrol / administration & dosage*
  • Resveratrol / chemistry
  • Silicon Dioxide / chemistry
  • Solubility

Substances

  • Emulsions
  • Excipients
  • Silicon Dioxide
  • Carboxymethylcellulose Sodium
  • Resveratrol