IgG Fc glycosylation as an axis of humoral immunity in childhood

Hao D Cheng; Irit Tirosh; Noortje de Haan; Henning Stöckmann; Barbara Adamczyk; Ciara A McManus; Róisín O'Flaherty; Gordon Greville; Radka Saldova; Francisco A Bonilla; Luigi D Notarangelo; Gertjan J Driessen; Ingrid A Holm; Pauline M Rudd; Manfred Wuhrer; Margaret E Ackerman; Peter A Nigrovic

doi:10.1016/j.jaci.2019.10.012

IgG Fc glycosylation as an axis of humoral immunity in childhood

J Allergy Clin Immunol. 2020 Feb;145(2):710-713.e9. doi: 10.1016/j.jaci.2019.10.012. Epub 2019 Oct 24.

Authors

Hao D Cheng¹, Irit Tirosh², Noortje de Haan³, Henning Stöckmann⁴, Barbara Adamczyk⁴, Ciara A McManus⁴, Róisín O'Flaherty⁴, Gordon Greville⁴, Radka Saldova⁵, Francisco A Bonilla⁶, Luigi D Notarangelo⁷, Gertjan J Driessen⁸, Ingrid A Holm⁹, Pauline M Rudd⁴, Manfred Wuhrer³, Margaret E Ackerman¹⁰, Peter A Nigrovic¹¹

Affiliations

¹ Molecular and Cellular Biology Program, Dartmouth College, Hanover, NH.
² Division of Immunology, Boston Children's Hospital, Boston, Mass; Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Israel.
³ Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
⁴ Glycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland.
⁵ Glycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland; College of Health and Agricultural Science, UCD School of Medicine, University College Dublin, Dublin, Ireland.
⁶ Division of Immunology, Boston Children's Hospital, Boston, Mass.
⁷ Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
⁸ Department of Pediatrics, Juliana Children's Hospital, Haga Teaching Hospital, The Hague, The Netherlands; Department of Pediatrics, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
⁹ Division of Endocrinology, Boston Children's Hospital, Boston, Mass.
¹⁰ Molecular and Cellular Biology Program, Dartmouth College, Hanover, NH; Thayer School of Engineering, Dartmouth College, Hanover, NH. Electronic address: Margaret.e.ackerman@dartmouth.edu.
¹¹ Division of Immunology, Boston Children's Hospital, Boston, Mass; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass. Electronic address: pnigrovic@bwh.harvard.edu.

Abstract

IgG Fc glycans were characterized in 225 healthy children and 40 children with unexplained recurrent respiratory infections, revealing age-dependent variation and suggesting a role for IgG glycosylation in immunocompetence.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Female
Glycosylation
Humans
Immunity, Humoral / immunology*
Immunoglobulin Fc Fragments / chemistry
Immunoglobulin Fc Fragments / immunology*
Immunoglobulin G / immunology*
Infant
Male

Substances

Immunoglobulin Fc Fragments
Immunoglobulin G
glycosylated IgG

Abstract

Publication types

MeSH terms

Substances

Grants and funding