Food Allergy Testing

Nicole A LaHood; Sarita U Patil

doi:10.1016/j.cll.2019.07.009

Food Allergy Testing

Clin Lab Med. 2019 Dec;39(4):625-642. doi: 10.1016/j.cll.2019.07.009. Epub 2019 Oct 3.

Authors

Nicole A LaHood¹, Sarita U Patil²

Affiliations

¹ Allergy and Immunology, Department of Medicine, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA, USA.
² Department of Medicine, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA, USA; Food Allergy Center, Massachusetts General Hospital for Children, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: sarita.patil@mgh.harvard.edu.

PMID: 31668274
DOI: 10.1016/j.cll.2019.07.009

Abstract

Although the gold standard for diagnosis of immunoglobulin E (IgE)-mediated food allergy is an oral food challenge, clinically relevant biomarkers of IgE sensitization, including serum-specific IgE and skin prick testing, can aid in diagnosis. Clinically useful values have been defined for individual foods. More recently, specific IgE to particular protein components has provided additional diagnostic value. In summary, food allergy diagnostics to evaluate IgE sensitization are clinically useful and continue to evolve to improve evaluation of IgE-mediated food allergies.

Keywords: Component testing; Food allergy; Immunoglobulin E; Oral food challenge; Skin testing.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Adolescent
Child
Child, Preschool
Food Hypersensitivity / blood
Food Hypersensitivity / diagnosis*
Food Hypersensitivity / physiopathology
Humans
Immunoglobulin E / blood
Immunologic Tests*
Infant
Sensitivity and Specificity
Skin Tests

Substances

Immunoglobulin E

Grants and funding

K23 AI121491/AI/NIAID NIH HHS/United States