Nontransplant Surgery for Intestinal Failure

Gastroenterol Clin North Am. 2019 Dec;48(4):565-574. doi: 10.1016/j.gtc.2019.08.009. Epub 2019 Oct 4.

Abstract

Insufficient absorptive mucosal surface is the fundamental problem in the short bowel state. Intestinal adaptation has been well studied, and it is well recognized that it may lead to dilatation of the bowel with increased thickness of the bowel wall, resulting from both mucosal hypertrophy and hyperplasia. Autologous reconstructive surgery exploits bowel dilatation in short bowel syndrome and maximizes the absorptive potential of the available mucosal surface. Indeed, autologous gastrointestinal reconstructive procedures may be better viewed as optimizing bowel diameter rather than focusing on length, thus allowing better prograde peristalsis and improved contact between luminal nutrients and mucosa, ultimately enhancing absorption.

Keywords: Adaptation; Autologous reconstruction; Dilatation; Lengthening; Short bowel syndrome.

Publication types

  • Review

MeSH terms

  • Digestive System Surgical Procedures / methods*
  • Dilatation, Pathologic / surgery
  • Gastrointestinal Transit
  • Humans
  • Intestines / pathology
  • Intestines / surgery
  • Short Bowel Syndrome / surgery*
  • Tissue Expansion