Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

Cyril Gitiaux; Vincent Bondet; Nassima Bekaddour; Patrick Nusbaum; Arnaud Hubas; Isabelle Melki; Christine Bodemer; Pierre Quartier; Isabelle Desguerre; Yanick J Crow; Jean-Philippe Herbeuval; Darragh Duffy; Brigitte Bader Meunier; Mathieu P Rodero

doi:10.1093/rheumatology/kez508

Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

Rheumatology (Oxford). 2020 May 1;59(5):1171-1174. doi: 10.1093/rheumatology/kez508.

Authors

Cyril Gitiaux^{1

2

3}, Vincent Bondet^{4

5}, Nassima Bekaddour⁶, Patrick Nusbaum⁷, Arnaud Hubas⁷, Isabelle Melki^{8

9

10

11}, Christine Bodemer^{12

13

14}, Pierre Quartier^{10

11

14}, Isabelle Desguerre^{15

16}, Yanick J Crow^{8

17}, Jean-Philippe Herbeuval⁶, Darragh Duffy^{4

5}, Brigitte Bader Meunier^{10

11

14}, Mathieu P Rodero⁶

Affiliations

¹ Reference Centre for Neuromuscular Diseases, Necker-Enfants Malades Hospital.
² Department of Paediatric Neurophysiology, Necker-Enfants Malades Hospital, Paris University, APHP Centre, Paris.
³ INSERM U955-Team 10, Department of Neurosciences, Mondor Biomedical Research Institute, Paris-Est University, Créteil.
⁴ Immunobiology of Dendritic Cells, Institut Pasteur, Paris.
⁵ INSERM U1223.
⁶ Chimie & Biologie, Modélisation et Immunologie pour la Thérapie (CBMIT), Université Paris Descartes, CNRS, UMR8601.
⁷ Laboratoire de Génétique et Biologie Moléculaires, Hôpital Cochin.
⁸ Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute.
⁹ General Paediatrics, Infectious Disease and Internal Medicine Department, Hôpital Robert Debré, AP-HP.
¹⁰ Paediatric Hematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, AP-HP.
¹¹ Rheumatological and Auto-Immune diseaseS in children (RAISE) rare diseases centre.
¹² National and European Reference Centre for Rare Diseases of the Skin (MAGEC and ERN-Skin).
¹³ Department of Dermatology, Necker-Enfants Malades Hospital, APHP5.
¹⁴ Imagine Institute, Inserm U 1163, Paris University.
¹⁵ Reference Center for Neuromuscular Diseases, Necker-Enfants Malades Hospital, AP-HP.5.
¹⁶ Department of Pediatric Neurology, Necker-Enfants Malades Hospital, AP-HP.5, Paris University, Paris, France.
¹⁷ Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

PMID: 31665500
DOI: 10.1093/rheumatology/kez508

No abstract available

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Cells, Cultured / drug effects
Cohort Studies
Dermatomyositis / diagnosis
Dermatomyositis / drug therapy*
Dermatomyositis / metabolism*
Enzyme-Linked Immunosorbent Assay / methods
Female
Humans
Interferon-alpha / drug effects
Interferon-alpha / genetics*
Interferon-alpha / metabolism
Male
Protein Serine-Threonine Kinases / antagonists & inhibitors*
Protein Serine-Threonine Kinases / pharmacology
Protein Transport / drug effects
Sensitivity and Specificity
Severity of Illness Index
Single Molecule Imaging
Young Adult

Substances

Interferon-alpha
Protein Serine-Threonine Kinases