High Prevalence of Anal and Oral High-Risk Human Papillomavirus in Human Immunodeficiency Virus-Uninfected French Men Who Have Sex With Men and Use Preexposure Prophylaxis

Ralph-Sydney Mboumba Bouassa; Laurent Bélec; Camelia Gubavu; Hélène Péré; Mathieu Matta; Artur Maka; Julien Puech; Serge Tonen Wolyec; David Veyer; Anne Gravier; Laurent Hocqueloux; Thierry Prazuck

doi:10.1093/ofid/ofz291

High Prevalence of Anal and Oral High-Risk Human Papillomavirus in Human Immunodeficiency Virus-Uninfected French Men Who Have Sex With Men and Use Preexposure Prophylaxis

Open Forum Infect Dis. 2019 Jun 19;6(9):ofz291. doi: 10.1093/ofid/ofz291. eCollection 2019 Sep.

Authors

Affiliations

¹ Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris and Université Paris Descartes, Paris Sorbonne Cité, France.
² Ecole Doctorale Régionale en Infectiologie Tropicale, Franceville, Gabon.
³ Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Régional d'Orléans, and the Centre Gratuit d'Information, de Dépistage et de Diagnostic d'Orléans, France.
⁴ Faculté de Médecine et de Pharmacie, Université de Kisangani, Kisangani, Democratic Republic of the Congo.

Abstract

Background: We assessed the prevalence and risk factors of anal and oral high-risk (HR) human papillomavirus (HPV) infection in human immunodeficiency virus-uninfected men who have sex with men (MSM) and take preexposure prophylaxis (PrEP) in France.

Methods: Anal and oral samples were screened by multiplex real-time polymerase chain reaction (Anyplex II HPV 28; Seegene) for HPV DNA.

Results: A total of 61 unvaccinated MSM (mean age, 36.1 years) were enrolled. Anal HPV and HR-HPV prevalences were 93.4% and 81.9%, respectively, and oral HPV and HR-HPV prevalences, 33.9% and 19.6%, respectively. HR-HPV type 33 was the most detected genotype, in both anal and oral samples. Among MSM, 68.8% carried ≥1 anal HPV type targeted by the 9-valent Gardasil-9 vaccine; all oral HPV-positive samples carried ≥1 strain included in the vaccine. Condomless receptive anal intercourse and history of anal gonorrhea were the main factors associated with increased risk for anal HPV infection (adjusted odds ratio, 10.4) and anal infection with multiple HR-HPV genotypes (5.77), respectively. Conversely, having had <10 partners in the last 12 months was associated with decreased risk for anal carriage of both multiple HPV (adjusted odds ratio, 0.19) and HR-HPV (0.17) types.

Conclusion: French MSM using PrEP are at high risk for both anal and oral carriage of HR-HPV that could lead to HPV-related cancers.

Keywords: Anal and oral HR-HPV; France; HIV preexposure prophylaxis; men who have sex with men; sexual risk behavior; sexually transmitted infections.