A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes

Valerie A Kickhoefer

doi:10.1074/jbc.H119.011130

A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes

J Biol Chem. 2019 Oct 25;294(43):15575-15576. doi: 10.1074/jbc.H119.011130.

Author

Valerie A Kickhoefer^{1

2}

Affiliations

¹ Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 vkick@ucla.edu.
² Vault Nano Inc., Los Angeles, California 90095.

Abstract

Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.

Publication types

Editorial
Comment

MeSH terms

RNA Splicing
RNA, Messenger
RNA, Small Untranslated*
Trypanosoma brucei brucei*
Vault Ribonucleoprotein Particles

Substances

RNA, Messenger
RNA, Small Untranslated
Vault Ribonucleoprotein Particles