Construction of DOX/APC co-loaded BiOI@CuS NPs for safe and highly effective CT imaging and chemo-photothermal therapy of lung cancer

Abstract

Recently, a variety of nanoparticles have been widely used as imaging agents or carriers for the diagnosis and therapy of lung cancer. However, their poor imaging effect, high toxicity, pro-inflammatory effect and ineffective treatment are still a great challenge. In this work, we reported a novel kind of BiOI@CuS nanoparticle to achieve safe and effective therapy of lung cancer by co-loading hydrochloric acid doxorubicin (DOX) and aspirin phenacetin and caffeine (APC). The nanoparticles can effectively relieve inflammatory reactions induced by photo-thermal therapy (PTT). In vitro and in vivo assays showed that DOX/APC co-loaded BiOI@CuS exhibited an effective chemo-photothermal comprehensive therapy effect and good CT imaging capability. Consequently, this multifunctional nanosystem provides a versatile and promising platform in the imaging and treatment of lung cancer in further applications.