Homology Modeling of P2X Receptors

Anastasios Stavrou; Sudad Dayl; Ralf Schmid

doi:10.1007/978-1-4939-9717-6_4

Homology Modeling of P2X Receptors

Methods Mol Biol. 2020:2041:65-75. doi: 10.1007/978-1-4939-9717-6_4.

Authors

Anastasios Stavrou¹, Sudad Dayl², Ralf Schmid^{3

4}

Affiliations

¹ Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
² Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq.
³ Department of Molecular and Cell Biology, University of Leicester, Leicester, UK. R.Schmid@le.ac.uk.
⁴ Leicester Institute of Structural and Chemical Biology (LISCB), University of Leicester, Leicester, UK. R.Schmid@le.ac.uk.

PMID: 31646480
DOI: 10.1007/978-1-4939-9717-6_4

Abstract

Since the X-ray structure of the zebra fish P2X4 receptor in the closed state was published in 2009 homology modeling has been used to generate structural models for P2X receptors. In this chapter, we outline how to use the MODELLER software to generate such structural models for P2X receptors whose structures have not been solved yet.

Keywords: Homology modeling; Ion channel; MODELLER software; P2X receptor; Protein structure prediction.

MeSH terms

Amino Acid Sequence
Animals
Humans
Receptors, Purinergic P2X / chemistry*
Sequence Homology
Software*
Structural Homology, Protein*

Substances

Receptors, Purinergic P2X