Pathophysiology of cardiovascular disease in diabetes mellitus

Gerardo Rodriguez-Araujo; Hironori Nakagami

doi:10.1097/XCE.0000000000000141

Pathophysiology of cardiovascular disease in diabetes mellitus

Cardiovasc Endocrinol Metab. 2018 Feb 14;7(1):4-9. doi: 10.1097/XCE.0000000000000141. eCollection 2018 Mar.

Authors

Gerardo Rodriguez-Araujo^{1

2}, Hironori Nakagami³

Affiliations

¹ Clinical Research Innovation, ProSciento Inc., Chula Vista, California.
² Graduate School, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.
³ Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Abstract

Diabetes mellitus elicits cellular, epigenetic, and post-translational changes that directly or indirectly affect the biology of the vasculature and other metabolic systems resulting in the apparition of cardiovascular disease. In this review, we provide a current perspective on the most recent discoveries in this field, with particular focus on hyperglycemia- induced pathology in the cardiovascular system. We also provide perspective on the clinical importance of molecular targeting of cardiovascular and diabetes mellitus therapies to treat hyperglycemia, inflammation, thrombosis, dyslipidemia, atherosclerosis, and hypertension.

Keywords: atherosclerosis; cardiovascular disease; cell signaling; cholesterol toxicity; diabetes mellitus; dyslipidemia; epigenetics; glucose toxicity; inflammation; pathophysiology.

Publication types

Review