Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice

Bo Hu; Gil Friedman; Eran Elinav; Richard A Flavell

doi:10.4161/2162402X.2014.981995

Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice

Oncoimmunology. 2018 May 7;8(10):e981995. doi: 10.4161/2162402X.2014.981995. eCollection 2019.

Authors

Bo Hu¹, Gil Friedman², Eran Elinav², Richard A Flavell^{1

3}

Affiliations

¹ Department of Immunobiology; Yale University School of Medicine; New Haven, CT USA.
² Immunology Department; Weizmann Institute of Science; Rehovot, Israel.
³ Howard Hughes Medical Institute; Yale University School of Medicine; New Haven, CT USA.

Abstract

The microbiota is pivotal in orchestrating the pathogenesis of IBD-associated colorectal cancer (CRC). We recently demonstrated that altered elements in the microbiota of inflammasome-deficient mice drive transmissible inflammation-induced CRC. This microbiota-mediated effect is dependent upon microbiome-induced CCL5-driven inflammation, which, in turn, promotes epithelial cell proliferation through local activation of the IL-6 pathway, leading to cancer development.

Keywords: ASC; Inflammasome; NLRP6; colon cancer; microflora.