Intratumoral CD8⁺ T cells with stem cell-like properties: Implications for cancer immunotherapy

Sci Transl Med. 2019 Oct 23;11(515):eaay6863. doi: 10.1126/scitranslmed.aay6863.

Authors

Werner Held¹, Imran Siddiqui², Karin Schaeuble², Daniel E Speiser¹

Affiliations

¹ Department of Oncology, University of Lausanne, Ch. des Boveresses 155, CH-1066 Lausanne, Switzerland. werner.held@unil.ch daniel.speiser@unil.ch.
² Department of Oncology, University of Lausanne, Ch. des Boveresses 155, CH-1066 Lausanne, Switzerland.

PMID: 31645454
DOI: 10.1126/scitranslmed.aay6863

Abstract

Intratumoral PD-1⁺ TCF1⁺ CD8⁺ T cells with stem cell-like properties mediate cellular expansion and tumor control in response to immunotherapy.

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Publication types

Review

MeSH terms

CD8-Positive T-Lymphocytes / metabolism*
Hepatocyte Nuclear Factor 1-alpha / metabolism
Humans
Immunotherapy / methods*
Neoplasms / immunology
Neoplasms / metabolism
Neoplasms / therapy*
Programmed Cell Death 1 Receptor / metabolism

Substances

HNF1A protein, human
Hepatocyte Nuclear Factor 1-alpha
Programmed Cell Death 1 Receptor