Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

Chak-Shing Kwan; Tao Wang; Min Li; Albert S C Chan; Zongwei Cai; Ken Cham-Fai Leung

doi:10.1039/c9cc06200a

Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

Chem Commun (Camb). 2019 Nov 18;55(89):13426-13429. doi: 10.1039/c9cc06200a. Epub 2019 Oct 23.

Authors

Chak-Shing Kwan¹, Tao Wang¹, Min Li², Albert S C Chan³, Zongwei Cai¹, Ken Cham-Fai Leung¹

Affiliations

¹ Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China. cfleung@hkbu.edu.hk zwcai@hkbu.edu.hk.
² School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China.
³ School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, P. R. China.

PMID: 31642458
DOI: 10.1039/c9cc06200a

Abstract

Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.